Endocrine Abstracts

Hyperthyroid rats and humans exhibit increased energy expenditure and marked hyperphagia. Recent evidence has pointed that alterations of thermogenesis linked to hyperthyroidism are associated to dysregulation of hypothalamic AMPK and fatty acid metabolism; however, the central mechanisms mediating hyperthyroidism-induced hyperphagia remain largely unclear.Objective: The aim of our study was to assess if alterations in feeding in hyperthyroidism are asso...

Ghrelin is a peptide hormone secreted by the stomach with orexigenic properties that induce food intake trough the activation of hypothalamic AMP activated kinase (AMPK). In rodents fed on normal diet the central administration of ghrelin induces an increase in food intake, however, when fed a high fat diet (HFD) rodents are resistant to the orexigenic effect of ghrelin. Recent data show that Cidea interacts with AMPK β-subunit and promotes AMPK degradation trough ubiquit...

Introduction: Smokers around the globe commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. In addition, numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action. Nicotine’s effects on energy homeostasis have been mostly pinpointed in the central nervous system, but the molecular mechanisms controlling its action are still not fully understood...

Aims: End stage renal disease is associated with disorders of calcium and phosphate metabolism that favor the loss of bone mass.Kidney transplant may alter this unbalance restoring bone mass. Nevertheless, recent studies showed that 48 months after transplant, the loss of bone mass still is superior to general population. Post-transplant corticosteroid therapy is considered the main responsible for the loss of bone mass.The authors...